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In a recent review, we claimed the identification as well as characterization of a whole new atypical opioid receptor with exceptional unfavorable regulatory properties in the direction of opioid peptides.1 Our benefits confirmed that ACKR3/CXCR7, hitherto called an atypical scavenger receptor for chemokines CXCL12 and CXCL11, can also be a wide-sp